Web Banner-01


Web Banner-02

Synthesis of Brodifacoum, Bromadiolone, Difenacoum


  • Brodifacoum Technical Material > 98%
  • China MOA Reg. No.: PD20070323
  • The most active coumarin-anticoagulant rodenticide, ideal for controlling larger pests, with a complex 8-step synthesis.


  • Bromadiolone Technical Material > 98%
  • China MOA Reg. No.: PD20070322
  • The most widely used 2nd-generation anticoagulant rodenticide, a 4-step manufactured coumarin derivative.


  • C22H20O (Difenacoum Intermediate) > 99.5%
  • Pesticide Intermediates Reg.: MEP/2011009
  • Synthesized in the same manner as Brodifacoum without the Bromine, ecologically safer, especially for birds.

2017 – China’s new pesticide regulations

  • China pesticide regulation (State Decree No. 677)
    On Feb. 8, 2017, the State Council of China approved an amendment to the “Regulation on the Administration of Pesticides” – know as the State Decree No. 677, coinciding with repeal of the 2001 State Decree No. 326.
  • China rodenticide restriction (MOA Proclamation No. 2567)
    On Aug. 31, 2017, China’s Ministry of Agriculture (MOA) issued proclamation No. 2567, the “List of Restricted Pesticides”, with a total of 32 pesticides covering all 6 rodenticides registered in China, “Flocoumafen, Diphacinone sodium, Warfarin, Coumatetralyl, Bromadiolone and Brodifacoum”.

Qualified Rodenticide in China

  • “Designated-site Rodenticide,” a direct translation from Mandarin, means that the qualification of the rodenticide active ingredients manufactured in China is approved by three ministries: (i) pesticide (rodenticide) registration with the ICAMA, (ii) industrial production site (environmental & safety) evaluation conducted by MIIT, (iii) final authorisation from AQSIQ for national designation of manufacturing (qualified production).
  • The China AQSIQ has finally authorised the manufacture of 2 rodenticide active ingredients, Brodifacoum and Bromadiolone, coming at only 2 designated sites based on MOA registration and MIIT evaluation. Siyang Rodenticide Factory is currently the only licensed exporter of Brodifacoum TC and Bromadiolone TC in China, which comes with the statutory declarations of “UN 3027, CLASS 6.1, PG: I (Steel Container Packaging)” and HS Code: “2932209011/13”.

Rodenticides Controlled in China

  • Dec. 2, 2005: China’s National Industrial Policy – as laid out in the “Regulations on Promoting Industrial Structure Adjustment” in the “Catalogue for Guiding Industry Restructuring (updated 2019),” China has banned the manufacture of new rodenticides.
  • Aug. 31, 2017: According to MOA Proclamation No. 2567, rodenticides in China have been listed as restricted pesticides and will be subject to designation marketing management. This means that purchases are ID-verified and the issuance of a national license is required at designated sale sites.
  • Feb. 1, 2019: A new restricted pesticide permit was granted to the Siyang Rodenticide Factory, which is being used for state management of the legal authenticity and traceability of rodenticide active ingredients.

Siyang Rodenticide Factory was established in 1985 as a state-designated rodenticide manufacturing unit approved by the former Ministry of Chemical Industry.

Siyang Rodenticide Factory is currently a designated production site for technical rodenticides approved by the MIIT (Ministry of Industry and Information Technology).

Siyang Rodenticide Factory mainly supplies 98% Technical-grade materials of Brodifacoum and Bromadiolone, as well as two SGARs intermediates registered.

Reforms of rodenticide administration

In 2005, Siyang Rodenticide Factory participated in the Review Meeting of Chinese Rodenticides  held by the Institute for the Control of Agrochemicals, MOA (ICAMA): Brodifacoum and Bromadiolone were officially adopted as China’s national rodenticides.

In 2006, the SAC (Standardization Administration of China) and AQSIQ (General Administration of Quality Supervision, Inspection and Quarantine of China) jointly enacted national standards for Brodifacoum TC and Bromadiolone TC.

  • In 2008, the AQSIQ officially authorized and issued the “Manufacturing Permit of National Industrial Product” to the Siyang Rodenticide Factory for Brodifacoum TC and Bromadiolone TC.

  • In 2013, Siyang Rodenticide Factory obtained a renewed “Manufacturing Permit of National Industrial Product” for Brodifacoum Technical and Bromadiolone Technical, (Permit No. XK13-003-00347).

  • In 2019, in accordance with the 2017 State Decree No. 667 and MOA Proclamation No. 2567, Siyang Rodenticide Factory obtained the “Restricted Pesticide Permit (No. (SU) 32000010534),” replacing the former AQSIQ permit.

  • In 2021, due to relocation, Siyang Rodenticide Factory exchanged the “Restricted Pesticide License (updated No. (SU) 32000013199)” for a new location: the new address “North of Wujiang Road and west of Gedonghe Road in Siyang Economic Development Zone” officially became a state-designated sales site for rodenticides.